PBMCs stimulated with immune complexes formed by mixing cellular extracts from U937 cells and SLE patient serum at a 1:1000 dilution, a condition modified from the method suggested by Dr. Elkon’s group [19, 33], increased the expression of CMPK2 mRNA (Fig. 1a). The gene discussed is CMPK2; the disease is systemic lupus erythematosus.