Markers of endothelial dysfunction/activation (Ang-2; adjusted fold change: 0.61; 95% CI 0.45–0.82; p = 0.001 and Ang-2:1 ratio; adjusted fold change 0.38; 95% CI 0.24–0.62; p < 0.001) were significantly lower in COVID-19 than non-COVID-19 patients. Here, ANGPT2 is linked to endothelial dysfunction.