Both the polycystin-1 encoded by the Pkd1 gene, required for cilia function, and polaris encoded by the Tg737 gene, required for cilia structure, are reported to be crucial mechanosensitive molecules to control fluid flow through primary cilia in endothelial cells [22, 53]. Daple regulates the direction and coordination of motile cilia beating in the ependymal cells, and determines the direction of CSF flow [54]. Daple-deficient mice present communicating hydrocephalus [54], and mutation in human DAPLE causes autosomal recessive congenital hydrocephalus [55]. The gene discussed is CCDC88C; the disease is communicating hydrocephalus.