Both CTRPs and GDFs are key regulators of glucose and lipid homeostasis; this study was designed to understand the interplay between circulatory CTRP-2/CTRP9 and GDF-8/GDF-15 by insulin, lipid and the effect of exercise in healthy women, and subjects with PCOS. This evidence concerns the gene C1QTNF2 and polycystic ovary syndrome.