To further determine the role of circLIFR and MSH2 complex in bladder cancer CDDP chemosensitivity, we performed MSH2 knockdown in circLIFR-overexpressed bladder cancer cells, and observed that circLIFR induction of cell apoptosis upon CDDP treatment was reversed by knockdown of MSH2 (Fig. 4a to d), suggesting that the up-regulation of cell apoptosis and CDDP sensitivity by circLIFR was dependent on its interaction with MSH2. The gene discussed is MSH2; the disease is urinary bladder cancer.