Consistent with the RNA-seq results [22], circLIFR was significantly downregulated in bladder cancer tissues (Fig. 1b), while the expression of LIFR pre-mRNA (pLIFR) and mRNA (mLIFR) showed no significant difference between bladder cancer and paired normal tissues (Fig. S1, A and B). The gene discussed is LIFR; the disease is urinary bladder cancer.