SNCA and Parkinson disease: Nilotinib, a Tyrosine-protein kinase ABL1 inhibitor, was shown to inhibit protein aggregation, neurodegeneration, mitochondrial pyruvate carriers, and posttranslational modifications of α-synuclein in in mice with safety data already available for human use (PD Nilotinib, NCT02954978) (Pagan et al. 2016; Karuppagounder et al. 2014).