With the gain of obesity, a population of CCR2+ ATMs lacking galactose N-acetyl-galactosamine–specific lectin 1 expression (MGL1−) with high M1 and low M2a gene expression is recruited to and clusters around necrotic adipocytes, which express high levels of the inflammatory markers CD11c and TLR4. This evidence concerns the gene ITGAX and obesity due to melanocortin 4 receptor deficiency.