ADGRL1 and colorectal carcinoma: In the complex VP1 architecture, phylogenetically distant VAL1-B3 and ABI3-B3 are functionally equivalent in supporting ABA-dependent activation of CRC in transgenic plants, whereas in the same context phylogenetically less distant LEC2-B3 and FUS3-B3 are hyper-active causing ABA-independent induction of CRC.