Valle Cusso et al showed that glucose transporter-1 (Glut1) expression increases from naïve to TCM and TEM and that the susceptibility of CD4 T cell subsets to HIV infection matches their Glut1 expression and metabolic activity as HIV selectively infects highly metabolic CD4+ T cells, independent of their activation phenotype [40]. This evidence concerns the gene SLC2A1 and HIV infectious disease.