ASNS and leukemia: In addition, some tumors are sensitive to depletion or restriction of amino acids, including cysteine in tumors with deleted methylthioadenosine phosphorylase (MTAP) [10], serine in tumors with deleted p53 (TP53) [11], asparagine in leukemias with low expression of asparagine synthetase (ASNS) [12], asparagine in tumors with inhibition of the electron transport chain [13], and methionine in RAS-driven tumors [14].