In all cases except LIPC in blood, the sign of the mediating effect was in concordance with literature: higher SORT1 (liver) expression decreasing LDL levels [19,58,59], higher MRAS (artery) being hazardous for CAD [60–62], higher PHACTR1 (artery) being protective for CAD [63,64], higher CETP (liver) decreasing HDL levels [65], and higher LIPC (liver) decreasing HDL levels [66]. The gene discussed is LIPC; the disease is coronary artery disorder.