Therefore, the lack of Kv1.3 may be compensated for in vivo by other channels or pathways; however, Kv1.3 channel inhibition with 5-(4-Phenoxybutoxy)psoralen (PAP-1) reduces infarct size and neurological scores in the middle cerebral artery occlusion model of ischemic stroke in rats [55]. This evidence concerns the gene KCNA3 and ischemic stroke.