ROCK1nc mice were treated with GLZ or DEN alone, or with the combination as shown in Figure 8A over the 4-day tumour initiation period, which recapitulates the GLZ dosing regimen that reduced neutrophil recruitment (Figure 5B), hepatocyte death (Figure 5C) and liver damage as determined by serum ALT levels (Figure 5D). The gene discussed is GPT; the disease is neoplasm.