Many of the modifiers common to neuronal and glial mHTT-induced dysfunction are involved in the regulation of the actin cytoskeleton (RHOC, TIAM1, ENAH, and CFL2), vesicular trafficking (SNAP23, SNX9, and SNX18), and inflammation (JUN, GTF3A, and ATF3). Multiple reports have implicated components of these pathways in the pathogenesis of not only HD, but in other neurodegenerative disorders as well (Al-Ramahi et al., 2018; Bardai et al., 2018; Bondar et al., 2018). The gene discussed is CFL2; the disease is Huntington disease.