Intriguingly, loss-of-function variants in NRXN1-3, NLGN1, NLGN3, DLGAP3, and LRRTM1 have been associated with various disorders of synaptic dysfunction, including autism spectrum disorder (ASD), schizophrenia, and obsessive compulsive disorder (OCD) (Nakanishi et al., 2017; Jamain et al., 2003; Südhof, 2008; Vaags et al., 2012; Wang et al., 2018; Windrem et al., 2017). Here, LRRTM1 is linked to obsessive-compulsive disorder.