CD79A and allergic disease: Dysregulation of the active intestinal IgA response in the early gut is correlated with the development of allergic diseases.108 Dzidic et al. investigated of the correlation between the SIgA binding of the GM at 12 months of age, when the generation of active gut SIgA is fairly abundant,103 and the development of allergic manifestations at 7 years of age.108 They found that children with allergic and asthmatic symptoms showed an altered SIgA recognition pattern of gut bacteria, including a substantial loss of SIgA binding to Escherichia/Shigella, at 12 months of age.108