Igha−/− mice that received no passive SIgA during suckling exhibited NEC development rates that were similar to those of formula-fed mice, while the incidence of NEC in WT control mice was lower, further demonstrating the crucial role of IgA in NEC development.5 In accordance, the NEC incidence was substantially lower in breastfed infants than in those who were formula-fed.76 Similarly, prenatal stress reduced the IgA levels in mice, resulting in GM alteration in 2-week-old neonatal mice while increasing their susceptibility to experimental NEC.77 This evidence concerns the gene CD79A and necrotizing enterocolitis.