Immunohistochemical staining for EphA2 in MDA‐MB‐231 intratibial tumors revealed that EphA2 was predominantly expressed in tumor cells (Supplementary Information Fig. S1A, right panels) within bone and in associated blood‐vessel endothelium (Supplementary Information Fig. S1A, lower left panel), consistent with what we observed in human disease (Fig. 1B) and in our previous studies showing EphA2 expression in the majority of tumor‐associated vascular endothelium.37, 40, 41. This evidence concerns the gene EPHA2 and neoplasm.