To assess the potential role of EphA2 function in the context of breast cancer metastatic disease in the bone microenvironment, we first analyzed and compared EPHA2 transcript levels in human metastatic breast cancer patient datasets from bone, brain, and lung curated by the Human Cancer Metastasis database (http://hcmdb.i-sanger.com/index).31 This evidence concerns the gene EPHA2 and breast carcinoma.