Wnt signaling activity is linked to kidney disease in ADPKD.(19, 20) As LiCl is a known activator of Wnt signaling, our data support a model whereby PKD1‐truncating mutations, which are associated with more severe kidney disease, lead to osteoblasts with the most‐responsive cilia and accelerated mineralized matrix deposition rates. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.