Preosteoblast cells were isolated from bone biopsies obtained from patients with ADPKD and patients with non‐ADPKD CKD with adynamic bone as defined histologically by low BFRs(7, 8, 9) and biochemically by low‐circulating bone ALP levels.(9) Patients with ADPKD showed confirmed mutations in either PKD1 or PKD2. (40, 41, 42) Disease progression of ADPKD is associated with the type of PKD mutation present. This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.