Wnt signaling activity is linked to kidney disease in ADPKD.(19, 20) As LiCl is a known activator of Wnt signaling, our data support a model whereby PKD1‐truncating mutations, which are associated with more severe kidney disease, lead to osteoblasts with the most‐responsive cilia and accelerated mineralized matrix deposition rates. Here, PKD1 is linked to kidney disorder.