GLDC and lung carcinoma: GLDC is the rate-limiting component of the glycine cleavage system (GCS), a mitochondrial multimeric enzyme complex that breaks down glycine and concomitantly synthesizes a one-carbon unit, which is a crucial anabolic intermediate required for cell proliferation.[27] As GLDC is a metabolic oncogene previously reported in lung cancer,[19] and it locates on the serine/glycine metabolic shunt that diverts the glycolytic metabolites to the major anabolic pathways,[13] we characterized how Snail regulates the expression of GLDC in detail.