SNAI1 and cancer: Warburg effect denotes a prominent cancerous metabolic phenotype where proliferative cancer cells prefer partial catabolism of glucose in the cytoplasm to complete oxidation of the glucose carbon in the mitochondria.[26] We observed that Snail induction had negligible effects on the levels of the metabolites of the tricarboxylic acid (TCA) cycle [Figure 2, green shades], suggesting that mitochondrial oxidation likely remains as a significant bioenergetics source in support of the cellular commitment to EMT.