Interestingly, the relative protein expression of p-AKT/AKT and p-mTOR/mTOR was strikingly impaired by propofol, which was ameliorated by si-circ#1; however, anti-miR-645 could abrogate the amelioration induced by circ_0026344 deletion in CRC cells (Figure 6a and b). The gene discussed is AKT1; the disease is colorectal carcinoma.