In human colon adenocarcinoma cells, SLT induced cell cytotoxicity and apoptosis, and regulated the expression of CDK1, p27, p53, cyclin B1, cyclin E, caspase-3, caspase-8, caspase-9, Bcl-2, Bax, and cytochrome C activity [18]. The gene discussed is CCNE1; the disease is colon adenocarcinoma.