In AD, frequently reported dysregulated genes include amyloid-beta precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2), apolipoproteins, and lipid homeostasis, genes involved in endocytosis, and membrane-spanning 4 (MS4) family [9]. This evidence concerns the gene PSEN1 and Alzheimer disease.