In periodontitis, aberrant genes highlighted include interleukin-1, interleukin-6, interleukin-10, transforming growth factor-beta (TGF-β), tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), and matrix metalloproteinases (MMPs) among others [10]. The gene discussed is TNF; the disease is periodontitis.