Among the 48 feature selection-obtained crosstalk genes and periodontitis-related genes in the DisGeNET database, 12 common genes were identified as core crosstalk genes including C3, C4A, C4B, CXCL12, FCGR3A, FCGR3B, HSPB1, IL1B, MME, MMP3, PLAT, and VEGFA (Table 9). Here, HSPB1 is linked to periodontitis.