CD8A and diffuse large B-cell lymphoma: A higher percentage of regulatory T-cells (FoxP3+) has proven to be an independent prognostic factor in BCLs (13) and a recent study showed that higher percentages of CD5+ and CD8+ lymphocytes and lower CD4+/CD8+ ratio at diagnosis are associated with a lower likelihood of progression in dogs with DLBCL treated with chemo-immunotherapy (31).