Of note, several psoriasis and PsA-associated gene variants, including variants affecting the IL12B (5q31.1eq33.1), IL23A (12q13.3), TYK2, STAT3, and TRAF3IP2 genes, enhance T cell activation and cytokine signaling pathways mostly related with the IL-23/-17 axis (Bowes et al., 2015; Bojko et al., 2018). The gene discussed is IL23A; the disease is psoriasis.