Lastly, synovial tissue and infiltrating immune cells (increased in PsA when compared with RA) express vascular endothelial growth factor (VEGF) and MMP-9 proteins that are involved in the proliferation of capillaries and EMMRPIN/CD147, which positively regulates the expression of VEGF and MMPs (Yurchenko et al., 2010; Yamamoto, 2013; Rahat et al., 2020) (Figure 3). This evidence concerns the gene VEGFA and rheumatoid arthritis.