754 differentially methylated regions (DMRs) in PsA vs. HC controls, and 86 between PsA and Ps. DMRs associated with skin and/or joint disease (MBP, OSBPL5, SNORD115, HCG26), and joint disease (IL22, ELF5, PPP2R2D, PTPRN2, HCG26). This evidence concerns the gene PPP2R2D and arthropathy.