The upregulation of CST1 expression is closely associated with poor prognosis in breast cancer patients (Dai et al., 2017) and colon cancer (Li et al., 2017b; Jiang et al., 2018), consistent with our results verifying the expression of CST1 in esophageal cancer tissues and cell lines by immunohistochemistry (IHC) and western blotting. This evidence concerns the gene CST1 and esophageal cancer.