The upregulation of CST1 expression is closely associated with poor prognosis in breast cancer patients (Dai et al., 2017) and colon cancer (Li et al., 2017b; Jiang et al., 2018), consistent with our results verifying the expression of CST1 in esophageal cancer tissues and cell lines by immunohistochemistry (IHC) and western blotting. The gene discussed is CST1; the disease is malignant colon neoplasm.