NR1H3 and atherosclerosis: Furthermore, allicin's role in regulating lipid metabolism has been demonstrated: the allicin-induced upregulation of ABCA1 promotes cholesterol efflux and reduces lipid accumulation via PPARγ/LXRα signaling in THP 1 macrophage-derived foam cells, which plays an important role in reducing the risk of atherosclerosis (47).