THBS1 and neoplasm: A 18 kDa HBD comprising the amino acid sequence 1–174—but not intact TSP-1—was able to stimulate tubulogenesis (Ferrari do Outeiro-Bernstein et al., 2002) when physically incorporated into fibrin plugs, a 3D support largely considered as a “provisional matrix” comparable to inflammatory edema and tumor microenvironments (Dvorak, 2015).