Since tumor growth experiments in TSP-1-null mice indicate that the absence of the intact molecule leads to increased angiogenesis, the pro-angiogenic activity of the NH2 domain may be masked or outweighed by the anti-angiogenic activity of the TSRs and the C-terminal domain (Lawler et al., 2001; Xie et al., 2011). The gene discussed is THBS1; the disease is neoplasm.