After 14 days of periodontitis induction, the WT-ligature mice showed an increased expression of osteoclast markers Trap, Ctsk, Dcstamp, and Nfatc1 and decreased expression of osteoblast markers Runx2, Alp, Opn, and Osx, compared with the WT-sham group. The gene discussed is CTSK; the disease is periodontitis.