To look for the relationship between pyroptosis and periodontitis, first, a Pearson’s correlation analysis was conducted between GCF IL-1β level (IL-1β release was the typical event of pyroptosis) and probing depth (clinical index of periodontitis), which demonstrated a significant positive correlation in the two parameters (P < 0.0001, R = 0.6974) (Figure 1B). The gene discussed is IL1B; the disease is periodontitis.