In a search for DUBs that could regulate Yap/Taz-mediated transcriptional luciferase reporter, 8XGTIIC, in cultured liver cancer (HepG2) cells, Zhu et al. (2020) found that knockdown of USP10 had the strongest effect on 8XGTIIC expression among the 98 DUBs tested. This evidence concerns the gene USP10 and liver cancer.