Zhang et al. (2017a) found that OGT is a transcriptional target of Yap–TEAD, uncovering a positive feedback between Yap and global cellular O-GlcNAcylation. Indeed, in a tissue microarray analysis of over 200 liver cancer samples, a statistically significant positive correlation between Yap expression and global O-GlcNAcylation was observed (Peng et al., 2017). Here, YAP1 is linked to liver cancer.