In response to inflammatory cytokine, TAK1 binds and phosphorylates Yap/Taz independent of Lats1/2 to promote Yap/Taz degradation, which alleviates the inhibition of NFκB, leading to the induction of matrix-degrading enzymes and subsequently cartilage degradation during osteoarthritis pathogenesis (Deng et al., 2018). The gene discussed is YAP1; the disease is osteoarthritis.