Both groups found that O-GlcNAc transferase (OGT) interacts with and O-GlcNacylates Yap and that O-GlcNAcylation reduces Yap binding to, and phosphorylation by, Lats1/2, leading to increased Yap activity and Yap-driven tumor growth (Peng et al., 2017; Zhang et al., 2017a). Here, YAP1 is linked to neoplasm.