C5a and C5aR1 are also highly expressed in a variety of tumors, such as cervical cancer, lymphoma, lung cancer, melanoma, breast cancer, ovarian cancer, cholangiocarcinoma, gastric cancer, renal cancer, lymphoma, liver cancer, colon cancer, pancreatic cancer, and glioma. The gene discussed is C5AR1; the disease is familial pancreatic carcinoma.