Studies clear that C1q can participate in the recruitment of peripheral blood monocytes, suppress macrophage inflammation and inflammasome activation (Benoit et al., 2012), and C5a can activate the NF-κB pathway through the C5aR1 receptor and promote the M2 like polarization of TAMs, thereby inhibiting the tumor immune response and promoting tumor progression (Piao et al., 2018). This evidence concerns the gene C5 and neoplasm.