According to the CPTAC data, the protein expression of PKMYT1, ETF1, ECT2, BUB1B, and RECQL4 in tumor tissues was significantly increased, while the expression of TFRC was significantly reduced, and the expression of COCH and TUBB2B did not change significantly (PITX1 and CDC6 were not included) (Figure 7A). The gene discussed is RECQL4; the disease is neoplasm.