At present, despite tremendous efforts have been made to discover new biomarkers for early diagnosis of HCC, the diagnosis of HCC still depends on imaging (ultrasound B, CT or MRI) and alpha-fetoprotein (AFP) in clinical practice (Montal et al., 2019; Timo Alexander et al., 2020; Zech et al., 2020). Here, AFP is linked to hepatocellular carcinoma.