The higher expression level of cyclooxygenase-2 (COX-2), also known as prostaglandin endoperoxide synthase 2 (PTGS2) – a recognized marker of ferroptosis – was observed in the heart of murine model with sepsis (Shen et al., 2007; Frazier et al., 2012; Yang et al., 2014). The gene discussed is PTGS2; the disease is Sepsis.