Ni et al. (2018) reported that knockdown of the expression of lncRNA GHET1 can increase the expression of Numb protein, thereby inhibiting the cell activity of the glioma. Prostate cancer cell proliferation is also enhanced by lncRNA GHET1, which functions through increasing the HIF-1α/Notch-1 signaling activity by binding to KLF2 (Zhu et al., 2019). Notably, Han et al. (2019) found that the inhibition of lncRNA GHET1 can downregulate the expression of EGFR protein and inhibit PI3K/AKT signaling activity, thereby inhibiting the cellular activities of breast cancer. Here, GHET1 is linked to central nervous system cancer.