With continuous research on bone metastasis, more and more experiments have put forth the concept of “pre-metastatic lesions;” that is, after tumor cells reach the target organ, they become infiltrating tumor cells and enter a dormant period (i.e., no proliferation or activation in the short term, Ki67-negative) (Ren et al., 2015; Wang et al., 2018). Here, MKI67 is linked to neoplasm.