Consistent with the role exerted during neural development, CHD7 is also implicated in tumors affecting CNS and NC-derived tissues, including medulloblastoma, glioblastoma, and neuroblastoma (Robinson et al., 2012; Badodi et al., 2017; Mondal et al., 2018; Boyd et al., 2019; Machado et al., 2019) (see Chapter 5). Here, CHD7 is linked to glioblastoma.