Hence, SOX2 and CHD7 are correlated and co-regulate a set of common target genes including JAG1, GLI3, and MYCN, which are mutated in different forms of cancers as well as in Alagille, Pallister-Hall, and Feingold syndromes, that share some clinical traits with CHARGE (Basson and van Ravenswaaij-Arts, 2015; Pauli et al., 2017; see also Table 1). This evidence concerns the gene CHD7 and cancer.