First, the results confirm high expression of WNT5A, FZD2, FZD5, and FZD7 in GC, while the analysis shows that ROR2 and FZD2 expression correlates with lower survival, and the combined WNT5A/FZD2/ROR2 and WNT5A/FZD7/ROR2 signatures strongly correlates with a worse prognosis. This evidence concerns the gene FZD2 and gastric cancer.