In contrast, despite the high levels of the canonical co-receptors LRP5/LRP6 and the ligand WNT2, the latter previously reported to be overexpressed in GC (Katoh, 2001; Zhang et al., 2018) and likely involving Wnt/β-catenin signaling (Cheng et al., 2005), these genes were not correlated with either OS or RFS, even when evaluated as a signature. This evidence concerns the gene LRP6 and gastric cancer.