Importantly, when the WNT2/LRP5/LRP6 canonical Wnt signature was used for analysis using STAD tumor data, the modest correlation with TAMs (compare lines 2b, 6b, and 10b in Supplementary Table 3) and M2 markers (compare lines 4b, 8b, and 12b in Supplementary Table 3) was lost, favoring a role for the non-canonical Wnt pathway in macrophage infiltration. The gene discussed is LRP5; the disease is neoplasm.