The neuroprotective effect of ghrelin is robust and reproducible as successfully demonstrated in a variety of animal models of neurodegenerative diseases and other neuronal injuries such as ischemia, traumatic brain injury, spinal cord injury, and amyotrophic lateral sclerosis (for a review, see Fields et al., 2011; Dos Santos et al., 2013; Stoyanova, 2014). Here, GHRL is linked to amyotrophic lateral sclerosis.