Recently, the results of a single-center, open-label pilot study involving 11 patients with AGS treated with abacavir, lamivudine, and zidovudine for 12 months were published, demonstrating a reduction in IFN signature and IFN activity in the cerebrospinal fluid and an increase in cerebral blood flow in three of the five patients evaluated. The gene discussed is IFNA1; the disease is Aicardi-Goutieres syndrome.