IFNA1 and systemic lupus erythematosus: The term “interferonopathy” first appeared in 2003, when some authors identified phenotypic overlaps between Aicardi–Goutieres syndrome (AGS) encephalopathy, viral congenital infections, and some autoimmune diseases such as systemic lupus erythematosus (SLE), postulating a common pathological feature as an upregulation of interferon (IFN) α activity (3).