PI3 and cancer: We noted an upsurge in interest of investigators to find out the mechanisms of compounds in the cancer treatment, and because of the report of different investigations, the possible specificity of these natural compounds in the sensitization of the abnormal cells that triggered different molecules that conduced to cellular damage by the activation of apoptosis, the induction of this pathway could be related by the activation of other pathways such as caspases, activation of PI3/AKT/mTOR and DNA double-strand break.