HERC2 and ovarian carcinoma: HERC2 also contains a mind bomb (MIB) domain that is thought to be involved in regulating the Notch signaling pathway to ensure proper intercellular communication during embryonic stem cell differentiation (107) and a downregulated in ovarian cancer (DOC) domain, which is similar to the anaphase promoting complex (APC) and may have a role in in the ubiquitylation activity of HERC2 (108).