WWP1 contains two WW domains that have been shown to recruit and modulate the activity of cancer related proteins like Runt-related transcription factor 2 (RUNX2) (153, 154), RING finger protein 11 (RNF11) (155, 156) and large tumor suppressor kinase 1 (LATS1) (157) via their proline-rich (PY) motifs (Figure 1). Here, RNF11 is linked to cancer.