The exogenous upregulation of miR-638 not only antagonizes the proliferation and metastasis of HCC cells through the targeted inhibition of oncogene Sp1 transcription factor (SP1), but also regulates the endothelial function and inhibits angiogenesis via the internalization of miR-638 overexpressed exosomes by HUVECs (87). The gene discussed is SP1; the disease is hepatocellular carcinoma.