As a competitive endogenous RNA, circFBLIM1 deinhibits the expression of the downstream target gene LDL receptor related protein 6 (LRP6) by negatively regulating the expression of miR-338, thereby initiating tumor cell glycolytic metabolism phenotype transformation: High glucose consumption, increased production of lactic acid and ATP, upregulation of ECAR (reflecting the overall glycolytic flux) and downregulation of OCR (reflecting mitochondrial respiration). This evidence concerns the gene LRP6 and neoplasm.