ASMTL and hepatocellular carcinoma: ASMTL-AS1 plays a role of carcinogen: As the disease stage progresses, ASMTL-AS1 in serum exosomes of HCC patients shows an increasing trend with further increasing after RFA; clinicopathological studies have confirmed that the expression level of ASMTL-AS1 is closely related to tumor volume, distant metastasis, and TNM staging.