However, zinc could act as a tumor suppressor agent (20, 21), for example, the accumulation of zinc inhibits growth and proliferation of prostate cells (22), and zinc could induce apoptosis in prostate cancer cells through its direct effects on mitochondrial release of cytochrome C followed by activation of caspases-9 and -3 (23) and inhibition of nuclear factor kappa B (NF-kB) (24, 25). This evidence concerns the gene NFKB1 and neoplasm.