In this study, based on TCGA database analysis, we found that the expression of SLC39A1, SLC39A8, SLC39A12 and SLC39A14 were significantly higher in cancer tissues compared to normal tissue, while the SLC39A3, SLC39A4, SLC39A5, SLC39A6, SLC39A7, SLC39A9 and SLC39A13 were expressed higher in normal tissues. This evidence concerns the gene SLC39A1 and cancer.