In brief, SLC39A8 serves to pass zinc into the cytoplasm, and intracellular zinc activate P53, ERK1/2 and apoptosis-related genes and pathways, and inhibit NF-kB, ICAM-1, AP-N, IL-8, and HIF-1α related signaling pathways by participating in a series of biological processes, finally leading to increased tumor cell death, and inhibition of EMT, tumor cell proliferation, invasion, and migration. The gene discussed is MAPK3; the disease is neoplasm.