In addition, the mechanisms of zinc inhibiting tumor reported in the existing literature include NF-kB signaling pathway (24, 25), Wnt-3a/β-catenin signaling pathway (61), P53 signaling pathway (62), hypoxia inducible factor-1α (HIF-1α) signaling pathway (63), apoptosis signaling pathway (64), and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway (65), etc. In a word, zinc could inhibit tumors by affecting many different signaling pathways. Here, TP53 is linked to neoplasm.