As shown in Supplementary Figures 1A–N, the expression of SLC39A1, SLC39A8, SLC39A12 and SLC39A14 in cancer tissues was significantly higher than that in normal tissues, however, the SLC39A3, SLC39A4, SLC39A5, SLC39A6, SLC39A7, SLC39A9 and SLC39A13 were expressed higher in normal tissues, and the expression of SLC39A2, SLC39A10 and SLC39A11 showed no significant difference between cancer and normal tissues. The gene discussed is SLC39A1; the disease is cancer.