In contrast, no information was available on NFAT3 and NFAT4 in this context, while a recent paper demonstrated that NFAT5 is overexpressed in CLL where it facilitates malignant cells survival and activation (84); yet, NFAT5 activation is not dependent on BCR but it is regulated by osmotic stress and inflammatory stimuli. The gene discussed is NFATC4; the disease is B-cell chronic lymphocytic leukemia.