NFAT5 and B-cell chronic lymphocytic leukemia: In contrast, no information was available on NFAT3 and NFAT4 in this context, while a recent paper demonstrated that NFAT5 is overexpressed in CLL where it facilitates malignant cells survival and activation (84); yet, NFAT5 activation is not dependent on BCR but it is regulated by osmotic stress and inflammatory stimuli.