CLL cells show higher mRNA levels of expression of both NFAT1 and NFAT2 as compared to normal lymphocytes (61); hypomethylation of the NFAT2 promoter region as well the first intron region may explain higher levels of both mRNA and protein in CLL as compared to normal B-cells types (62). This evidence concerns the gene NFATC2 and B-cell chronic lymphocytic leukemia.