DNMT3A and prostate adenocarcinoma: DNA methyltransferase 1 (DNMT1), DNMT3a, and DNMT3b are upregulated in PRAD tissue compared to normal benign prostatic hyperplastic tissue, and their expression is elevated in cancerous tissue with a higher Gleason score, suggesting a close association between epigenetic alterations and PRAD development and progression (10).