Differentially methylated genes with the Pearson's correlation coefficient >0.4 were identified, including fibromodulin (FMOD), transmembrane protein 220 (TMEM220), histone H2B type 1-H (HIST1H2BH), zinc finger 334 (ZNF334), RIC3 acetylcholine receptor chaperone (RIC3), and solute carrier family 7 member (SLC7A4); these genes were all hypermethylated in tumor samples (n = 336) compared to normal tissue (n = 49) (Figures 8A, 9A). Here, TMEM220 is linked to neoplasm.