The activation of mitogen-activated protein kinase (MAPK) family (p-JNK, p-ERK and p-p38 levels) and the downregulation of B-cell lymphoma 2 (Bcl-2) and matrix metalloproteinase 9 (MMP-9) were demonstrated to impair cell viability, proliferation, migration, invasion, tubule formation and increase apoptosis in breast cancer cells (50). Here, MMP9 is linked to breast carcinoma.