GLO1 and breast cancer: Similar effects are found in Glo1-depleted breast cancer cells where, the downregulation of the dual specificity phosphate 5 (DUSP5) phosphatase and the consequent over-activation of MEK/ERK/SMAD1 pathway promote the establishment of a metastatic phenotype characterized by increased cell migration and extracellular matrix (ECM) remodeling (67).