Our results showed that ERRFI1 was up-regulated in lung cancer cells after treatment with LC-C in vitro and in vivo, and the expression level of p-EGFR and p-STAT3 was decreased in A549-IR cells after treatment with LC-C, which revealed that ERRFI1 and EGFR/STAT3 may be critical molecules in the radiosensitization effect of LC-C. This evidence concerns the gene STAT3 and lung carcinoma.