HGF-positive EVs have been found in the BM of a subset of MM patients and a subset of cultured MM primary cells (52), and recently in vitro studies reported the delivery of HGF to OBLs, where it triggers the activation of its receptor Met, resulting in the inhibition of the osteogenic activity (52) and increased secretion IL-11 (53). Here, IL11 is linked to Miyoshi myopathy.