PKD2 and pharyngeal squamous cell carcinoma: Another example of the successful delivery of exosomal siRNA was reported by Wang et al., which showed that EVs loaded with transient receptor potential polycystic 2 (TRPP2) siRNA were able to reduce epithelial mesenchymal transition by suppressing TRPP2 expression in a cell line of human pharyngeal squamous cell carcinoma (114).