As a consequence of this activation, microglia release factors such as Matrix metalloproteinases (MMPs), Nitric oxide (NOS), Stress inducible protein-1 (STI-1), Arginase-1 (ARG-1), Interleukins (ILS) and COX2 that can be influence the progression of GBM (35) (Figure 2). The gene discussed is PTGS2; the disease is glioblastoma.