SOX2 and glioblastoma: It is important to note that Wnt/β-catenin highly activated sub-population of GSCs showed enhanced levels of expression of genes CD133, SRY-box 2 (SOX2), Nanog, Octamer-binding transcription factor-4 (Oct-4), and Nestin, which proposes the role of biomarkers-Wnt/β-catenin axis in remaining stemness traits of GBM (74).