It has been described the existence of negative regulators of the NF-κB pathway that could be involved in the constitutive activation of NF-κB in ATLL such as TNF-α-induced protein 3 (TNFAIP3, A20), Cylindromatosis (CYLD), and NSFL1 cofactor (p47) among others. Here, NFKB1 is linked to adult T-cell leukemia/lymphoma.