In addition, pituitary tumors can not only cause compression symptoms, but also cause a corresponding increase in the incidence of cardiovascular-related diseases, growth hormone-related metabolic abnormalities, high blood pressure, respiratory diseases, and malignant tumors such as thyroid nodules/thyroid cancer and colon cancer (10), resulting in a shortened life of patients with acromegaly. Here, GH1 is linked to hypertensive disorder.